Thursday, September 16, 2010

HIV/swine flu outcomes “remarkable”

Michael Carter for Aidsmap (16 September 2010)

No evidence that swine flu outcomes worse in patients with HIV

HIV-positive patients had a similar outcome to HIV-negative patients during the 2009/10 swine flu pandemic, Spanish researchers report in the online edition of AIDS.

Rates of secondary pneumonia, admission to intensive care, the use of mechanical ventilation and mortality were similarly low in both groups of patients.

Patients with HIV did not take any longer to recover from the infection, and did not require a longer stay in hospital.

The investigators describe these findings as “remarkable”.

Little is known about the outcome of HIV-positive patients who contracted swine flu. Only one fatality in an HIV-positive patient with the infection has so far been reported.

Therefore investigators undertook a prospective study in order to describe the symptoms, complications and outcomes of swine flu in HIV-positive patients who were admitted to 13 hospitals in Spain between June and November 2009. The characteristics of these HIV-positive patients were compared to HIV-negative swine flu patients to see if outcomes differed between these two groups.

“The fact that no differences in clinical outcomes were observed between HIV-1-infected and seronegative patients is remarkable”, comment the investigators.

They conclude, “in HIV patients, well controlled on HAART, the new influenza virus AH1N1 had similar clinical outcomes and prognosis to non-HIV patients.”


Clinical presentation and prognosis of the 2009 H1N1 influenza A infection in HIV-1-infected patients: a Spanish multicenter study.
Riera, Melchor; Payeras, Antoni; Marcos, Maria A; Viasus, Diego; Farinas, Maria C; Segura, Ferran; Torre-Cisneros, Julian; Martín-Quirós, Alejandro; Rodríguez-Baño, Jesús; Vila, Juan; Cordero, Elisa; Carratalà, Jordi
AIDS 24, advance online publication, September 4, 2010. DOI: 10. 1097/QAD.0bo13e32833e508f.

Link to AIDS abstract

Link to Aidsmap article

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