Thursday, September 02, 2010

females fare better

Science Daily (Aug. 31, 2010) —

Why Females Fare Better Than Males After Traumatic Injury

A new study looks at how female versus male rats fared after suffering a trauma and subsequent hemorrhagic shock who were given Estradiol (estrogen).

In the study, published in the September 2010 issue of Shock by Dr. Ed W. Childs and colleagues at Scott & White Healthcare, the Estradiol prevented vascular permeability following hemorrhagic shock.

"We've always known that females fare better than males after traumatic injury, but we never knew why, now we know a potential mechanism," said Ed W. Childs, M.D., professor of surgery at the Texas A&M Health Science Center College of Medicine, and vice chairman of research in the department of surgery at Scott & White Healthcare.

"This study proved that estrogen receptors on the mitochondria of our cells actually help protect these cells on females after injury. But, if you block those estrogen receptors, they perform like those of a male."

Examples of shock can include: car accident, falls that may include a severe trauma, and any injury that causes bleeding. Shock (level IV) is defined as 40% blood volume loss and a systolic blood pressure under 90.

Reference:

17β-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling.
Childs, Ed W, Tharakan Binu, Hunter Felicia A, Smythe W Roy
Shock, 2010; 34 (3): 229-235 DOI: 10.1097/SHK.0b013e3181d75b50

Link to Shock abstract

Link to Science Daily article

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