Friday, May 14, 2010

Alcohol consumption : informed decisions

Science Daily (May 13, 2010)

Frequent Alcohol Use Linked to Faster HIV Disease Progression

HIV tends to progress at a faster rate in infected individuals who consume two or more alcoholic drinks a day, according to new studies.

An article, entitled "Alcohol Use Accelerates HIV Disease Progression," clearly demonstrates that frequent alcohol use, defined as two or more drinks daily, is associated with declining CD4+ cell counts in individuals with HIV. Based on the results of a 30-month prospective study, the authors, conclude that alcohol has a direct effect on CD4 cells and that the accelerated decline in CD4+ cell counts in frequent alcohol users is not simply due to poorer adherence to ART in this population.

Another article by Natascha Ching et al demonstrated that children who were infected with HIV while in utero via maternal-fetal transmission, were subsequently given antiretroviral therapy, and had no detectable HIV in their blood, still produced neutralizing antibodies against HIV, suggesting that low levels of viral replication might still be occurring despite drug therapy. In the article, the authors present data to support their conclusion that the children's CD4 T-cells may contain latent HIV reservoirs that formed early in life before antiretroviral therapy was initiated.

"It is important that HIV infected individuals make informed decisions relating to alcohol consumption. This article will help to achieve that goal," says Thomas Hope, PhD, Editor-in-Chief of AIDS Research and Human Retroviruses and Professor of Cell and Molecular Biology at the Feinberg School of Medicine, Northwestern University, Chicago, IL.

Reference:

Autologous Neutralizing Antibody to Human Immunodeficiency Virus-1 and Replication-Competent Virus Recovered from CD4+ T-Cell Reservoirs in Pediatric HIV-1 Infected Patients on HAART.
Natascha Ching, Karin A. Nielsen-Saines, Jaime G. Deville, Lian S. Wei, Eileen Garratty, Yvonne J. Bryson.
AIDS Research and Human Retroviruses, Volume 26, Number 5, 2010 DOI: 10.1089/aid.2008.0274

Link to AIDS Research article [pdf]


Alcohol Use Accelerates HIV Disease Progression
Marianna K. Baum, Carlin Rafie, Shenghan Lai, Sabrina Sales, John Bryan Page and Adriana Campa
AIDS Research And Human Retroviruses, Volume 26, Number 5, 2010DOI: 10.1089/aid.2009.0211

Link to AIDS Research article [pdf]

Link to Science Daily article

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